In coupled reactions, energy is transferred from place to place by energy carrier molecules such as ATP. In this role as an intermediary in coupled reactions, ATP is constantly being synthesized to capture energy released during exergonic reactions and then broken down to power endergonic reactions (102). The electron transport chain converts energy and uses the exergonic flow of electrons to pump hydrogen ions across the mitochondrial membrane. In the DNP case hydrogen ions leaked back across the membrane, diffusing down its gradient.
When the mitochondrial membrane became leaky to hydrogen ions chemiosmosis stopped because there wasnt a gradient of protons between the outside and inside of the membrane. Without a gradient of protons the majority of the ATP produced by cellular respiration couldnt be produced which is essential to make fatty acids and breakdown glucose, therefore the energy in a persons metabolism comes from stored fat or protein, causing a person to lose weight as well as causing a lack of energy. In the same sense the body must find another source of energy to give the body enough ATP to survive, unfortunately in the DNP case it lead to death.