In order to organize the development of the theme, Vonnegut begins his novel by creating a sense of pointlessness for the characters to build off of, a blank slate. Newt, the son of Felix Hoenikker, who was the creator of the Atomic Bomb and Ice-nine, creates this mood in his description of the yarn game Cats Cradle. He asks John to point out the cat and cradle in the yarn formation, which he obviously cant; Vonnegut is commenting on humanitys attempts to find meaning where no meaning exists. It is with this notion in mind that John begins his exploration of science and religion.
Science is Johns first stop in his search for purpose. The author points out that in scientists desperate search for truth, which seems to be the only thing with importance, they arent intelligent enough to realize that the truth is given a false connotation. In the Hoenikkers case, the truth was the basis for millions of people being killed by the atomic bomb and the end of the world through Ice-nine. So, truth is rejected as innately good, which leaves John with nothing but lies and religion.
However, in San Lorenzo, lies and religion are a good combination. John is introduced to Bokononism when he gets his hands on a copy of The Books of Bokonon. The basis of this religion is that anything considered good, whether it be an organization, a cause, or a religion, is based on foma, or lies. Vonnegut comes back to his original point of humanity trying to give things meaning. John has only experienced the futility of this concept, but through Bokonon, he is able to see a different and more easily acceptable argument: Live by the harmless untruths that make you brave and kind and healthy and happy (Vonnegut 265, The Books of Bokonon). He begins to understand what Bokonon was getting at: that in attempting to give the world meaning, men lied in order to make life more interesting.
Johns character travels through Vonneguts moral maze, beginning with a supposedly meaningless world, finding that truth isnt always good, and realizing that lies are not only behind everything, but are good for the soul. Vonneguts character and theme come to rest when Ice-nine has replaced the worlds water and brought to pass the end of the world. John, as one of the only people left living, finally understands and accepts Bokonons idea that, although foma may be dangerous or harmful, lies are what make life worth living.